Award
NIH Reporter #3K08HL173572-03S1
The Impact of Soluble ST2 on Lung Injury Onset and Resolution
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$58,320.00
Ceiling
$58,320.00
Awarded
September 17, 2026
Identifier
3K08HL173572-03S1
Research project funded by the National Heart Lung and Blood Institute to study IL-33 signaling and soluble ST2 in lung injury and repair, targeting ARDS mechanisms and biomarkers.
Description
This project investigates the role of IL-33 signaling and its regulation by soluble ST2 in lung injury and repair, focusing on acute respiratory distress syndrome (ARDS). It aims to define the causal role of IL-33 and sST2 in ALI onset and resolution using murine models and longitudinal human data, with the goal of identifying biomarkers and therapeutic targets.