# NIH Reporter #3K08HL173572-03S1

The Impact of Soluble ST2 on Lung Injury Onset and Resolution

**Recipient:** Massachusetts General Hospital, Boston, MA, United States

**Award Amount:** $58,320.00
**Ceiling:** $58,320.00

**Awarded:** September 17, 2026

**Identifier:** 3K08HL173572-03S1

Research project funded by the National Heart Lung and Blood Institute to study IL-33 signaling and soluble ST2 in lung injury and repair, targeting ARDS mechanisms and biomarkers.

### Description

This project investigates the role of IL-33 signaling and its regulation by soluble ST2 in lung injury and repair, focusing on acute respiratory distress syndrome (ARDS). It aims to define the causal role of IL-33 and sST2 in ALI onset and resolution using murine models and longitudinal human data, with the goal of identifying biomarkers and therapeutic targets.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11631207)