Award
NIH Reporter #11459315
Regulation of HSV-1 Latency by hnRNPK
Recipient
University of Virginia
Award Amount
$39,780.00
Ceiling
$39,780.00
Awarded
August 05, 2026
Identifier
11459315
The project investigates hnRNPK's role in HSV-1 latency and reactivation, focusing on gene silencing mechanisms to identify new therapeutic targets to prevent viral reactivation.
Description
This project aims to investigate the mechanisms by which hnRNPK promotes HSV-1 reactivation-competent latency, focusing on its role in H2Aub1 deposition on the viral genome and the influence of the Latency Associated Transcript (LAT) on hnRNPK recruitment.