# NIH Reporter #11459315

Regulation of HSV-1 Latency by hnRNPK

**Recipient:** University of Virginia

**Award Amount:** $39,780.00
**Ceiling:** $39,780.00

**Awarded:** August 05, 2026

**Identifier:** 11459315

The project investigates hnRNPK's role in HSV-1 latency and reactivation, focusing on gene silencing mechanisms to identify new therapeutic targets to prevent viral reactivation.

### Description

This project aims to investigate the mechanisms by which hnRNPK promotes HSV-1 reactivation-competent latency, focusing on its role in H2Aub1 deposition on the viral genome and the influence of the Latency Associated Transcript (LAT) on hnRNPK recruitment.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11459315)