Award
NIH Reporter #2R01NS108769-06A1
Multimodal analysis and therapeutic targeting of aberrant nucleocytoplasmic compartmentalization in FUS-related neurodegenerative disease
Recipient
UNIV OF MASSACHUSETTS MED SCH WORCESTER
Award Amount
$1,123,020.00
Ceiling
$1,123,020.00
Awarded
September 14, 2026
Identifier
2R01NS108769-06A1
This award supports research on the role of FUS mutations in neurodegenerative diseases ALS and FTD, focusing on nucleocytoplasmic transport disruption and therapeutic targeting of protein kinase C.
Description
FUS is a critical, multifunctional RNA-binding protein associated with ALS and FTD. The project aims to investigate how FUS mutations disrupt nucleocytoplasmic transport and RNA processing using advanced microscopy, biochemical, structural, and genomic technologies in human and mouse models. The study will also explore therapeutic targeting of protein kinase C to mitigate FUS dysfunction.