Award
NIH Reporter #5P20GM148302-04
Synaptic Perturbations to Early Development of Sleep-Related Cortical Circuits
Recipient
Medical University of South Carolina
Award Amount
$109,182.00
Ceiling
$109,182.00
Awarded
October 29, 2026
Identifier
5P20GM148302-04
The project investigates whether embryonic synaptic activity is needed to establish cortical circuits that generate sleep-related synchrony after birth, and explores implications for sleep disruption in neurodevelopmental disorders.
Description
NIH-funded research on how embryonic Grin2b-related activity in Layer 5 pyramidal neurons shapes cortical synchrony associated with sleep, using in vivo imaging and optogenetics.