# NIH Reporter #5P20GM148302-04

Synaptic Perturbations to Early Development of Sleep-Related Cortical Circuits

**Recipient:** Medical University of South Carolina

**Award Amount:** $109,182.00
**Ceiling:** $109,182.00

**Awarded:** October 29, 2026

**Identifier:** 5P20GM148302-04

The project investigates whether embryonic synaptic activity is needed to establish cortical circuits that generate sleep-related synchrony after birth, and explores implications for sleep disruption in neurodevelopmental disorders.

### Description

NIH-funded research on how embryonic Grin2b-related activity in Layer 5 pyramidal neurons shapes cortical synchrony associated with sleep, using in vivo imaging and optogenetics.

[View original record](https://reporter.nih.gov/search/7U_RDKopbE--cH-2OrGcnA/project-details/11686419)