Award
NIH Reporter #1F31AG104842-01
Social Isolation Contributes to AD Pathogenesis and Risk by Reducing Cortical Blood Flow
Recipient
Virginia Polytechnic Institute and State University
Award Amount
$44,306.00
Ceiling
$44,306.00
Awarded
September 03, 2026
Identifier
1F31AG104842-01
The project examines whether social isolation reduces cerebral blood flow and promotes amyloid-beta accumulation at the astrocyte/meningeal interface, potentially contributing to Alzheimer’s disease. It will use mouse models, imaging, immunohistochemistry, and viral manipulations to test the role of pial aquaporin-4.
Description
Research fellowship project investigating how social isolation may contribute to Alzheimer’s disease through reduced cortical blood flow, with a focus on pial aquaporin-4 and amyloid-beta accumulation.