# NIH Reporter #1F31AG104842-01

Social Isolation Contributes to AD Pathogenesis and Risk by Reducing Cortical Blood Flow

**Recipient:** Virginia Polytechnic Institute and State University

**Award Amount:** $44,306.00
**Ceiling:** $44,306.00

**Awarded:** September 03, 2026

**Identifier:** 1F31AG104842-01

The project examines whether social isolation reduces cerebral blood flow and promotes amyloid-beta accumulation at the astrocyte/meningeal interface, potentially contributing to Alzheimer’s disease. It will use mouse models, imaging, immunohistochemistry, and viral manipulations to test the role of pial aquaporin-4.

### Description

Research fellowship project investigating how social isolation may contribute to Alzheimer’s disease through reduced cortical blood flow, with a focus on pial aquaporin-4 and amyloid-beta accumulation.

[View original record](https://reporter.nih.gov/search/a_XEnEpPR0i-06zXlbqcPw/project-details/11462057)