Award
NIH Reporter #5UG3AI190386-02
Mechanisms of Immediate Non-IgE-mediated Drug Hypersensitivity Reactions (MIND-HR)
Recipient
UT Southwestern Medical Center
Award Amount
$394,205.00
Ceiling
$394,205.00
Awarded
June 11, 2026
Identifier
5UG3AI190386-02
NIH funding supports UT Southwestern Medical Center's research into MRGPRX2-mediated drug hypersensitivity, including validation of diagnostic assays and tests to distinguish non-IgE-mediated reactions.
Description
A multiphase research project studying mechanisms of immediate non-IgE-mediated drug hypersensitivity reactions, using vancomycin infusion reactions to investigate MRGPRX2 expression and skin reactivity. The project aims to improve diagnosis and reduce misclassification and unnecessary drug avoidance.