# NIH Reporter #5UG3AI190386-02

Mechanisms of Immediate Non-IgE-mediated Drug Hypersensitivity Reactions (MIND-HR)

**Recipient:** UT Southwestern Medical Center

**Award Amount:** $394,205.00
**Ceiling:** $394,205.00

**Awarded:** June 11, 2026

**Identifier:** 5UG3AI190386-02

NIH funding supports UT Southwestern Medical Center's research into MRGPRX2-mediated drug hypersensitivity, including validation of diagnostic assays and tests to distinguish non-IgE-mediated reactions.

### Description

A multiphase research project studying mechanisms of immediate non-IgE-mediated drug hypersensitivity reactions, using vancomycin infusion reactions to investigate MRGPRX2 expression and skin reactivity. The project aims to improve diagnosis and reduce misclassification and unnecessary drug avoidance.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11378009)