Award
NIH Reporter #1F30DK146476-01A1
Establishing the Cholinergic Anti-Inflammatory Pathway in Pancreatic Islets
Recipient
University of Miami School of Medicine
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
August 03, 2026
Identifier
1F30DK146476-01A1
NIH research award to investigate how cholinergic signaling may regulate inflammation in pancreatic islets and influence type 1 diabetes progression.
Description
The project investigates whether local cholinergic innervation suppresses islet macrophage activation and protects pancreatic islets from autoimmune initiation in type 1 diabetes. It will study cholinergic neuron–macrophage interactions and test whether inhibiting local cholinergic neurons accelerates diabetes incidence in a mouse model.