# NIH Reporter #1F30DK146476-01A1

Establishing the Cholinergic Anti-Inflammatory Pathway in Pancreatic Islets

**Recipient:** University of Miami School of Medicine

**Award Amount:** $55,114.00
**Ceiling:** $55,114.00

**Awarded:** August 03, 2026

**Identifier:** 1F30DK146476-01A1

NIH research award to investigate how cholinergic signaling may regulate inflammation in pancreatic islets and influence type 1 diabetes progression.

### Description

The project investigates whether local cholinergic innervation suppresses islet macrophage activation and protects pancreatic islets from autoimmune initiation in type 1 diabetes. It will study cholinergic neuron–macrophage interactions and test whether inhibiting local cholinergic neurons accelerates diabetes incidence in a mouse model.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11463039)