Award
NIH Reporter #1P01CA298971-01A1
Research Project 2: Biomaterial-driven CAR T cell generation for treatment of GBM
Recipient
University of North Carolina Chapel Hill
Award Amount
$370,392.00
Ceiling
$370,392.00
Awarded
March 05, 2026
Identifier
1P01CA298971-01A1
NIH funding for the University of North Carolina Chapel Hill to develop and evaluate a biomaterial scaffold designed to generate CAR T cells in patients for treatment of glioblastoma.
Description
The project develops and tests a Multifunctional Alginate Scaffold for T cell Engineering and Release (MASTER) to generate and release CAR T cells in vivo for glioblastoma treatment. It will optimize scaffold properties and evaluate CAR T cell function, efficacy, persistence, biocompatibility, and immunogenicity in GBM models.