# NIH Reporter #1P01CA298971-01A1

Research Project 2: Biomaterial-driven CAR T cell generation for treatment of GBM

**Recipient:** University of North Carolina Chapel Hill

**Award Amount:** $370,392.00
**Ceiling:** $370,392.00

**Awarded:** March 05, 2026

**Identifier:** 1P01CA298971-01A1

NIH funding for the University of North Carolina Chapel Hill to develop and evaluate a biomaterial scaffold designed to generate CAR T cells in patients for treatment of glioblastoma.

### Description

The project develops and tests a Multifunctional Alginate Scaffold for T cell Engineering and Release (MASTER) to generate and release CAR T cells in vivo for glioblastoma treatment. It will optimize scaffold properties and evaluate CAR T cell function, efficacy, persistence, biocompatibility, and immunogenicity in GBM models.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11263857)