Award
NIH Reporter #1K99AI202747-01
Defining how Bacterial-Sensing Caspases Regulate RNA Metabolism and Immunity
Recipient
University of Pennsylvania
Award Amount
$147,166.00
Ceiling
$147,166.00
Awarded
September 18, 2026
Identifier
1K99AI202747-01
The award supports research into how human CASP4 and CASP5 cleave RNA-binding proteins during bacterial infection, with the goal of understanding their roles in RNA metabolism and host immunity and informing future therapeutic strategies.
Description
Research project investigating how inflammatory caspases cleave RNA-binding proteins to regulate RNA metabolism, cell fate, and innate immune responses during gram-negative bacterial infections.