# NIH Reporter #1K99AI202747-01

Defining how Bacterial-Sensing Caspases Regulate RNA Metabolism and Immunity

**Recipient:** University of Pennsylvania

**Award Amount:** $147,166.00
**Ceiling:** $147,166.00

**Awarded:** September 18, 2026

**Identifier:** 1K99AI202747-01

The award supports research into how human CASP4 and CASP5 cleave RNA-binding proteins during bacterial infection, with the goal of understanding their roles in RNA metabolism and host immunity and informing future therapeutic strategies.

### Description

Research project investigating how inflammatory caspases cleave RNA-binding proteins to regulate RNA metabolism, cell fate, and innate immune responses during gram-negative bacterial infections.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11436878)