Award
NIH Reporter #1DP2NS155520-01
RNA-Templated DNA Repair as a Genome Maintenance Pathway in Neurons
Recipient
Alessandra Brambati
Award Amount
$741,000.00
Ceiling
$741,000.00
Awarded
September 17, 2026
Identifier
1DP2NS155520-01
Research project funded by NINDS to study RNA-templated DNA repair in neurons, exploring its role in genome maintenance and implications for neurological diseases.
Description
This project aims to define how RNA-templated DNA repair maintains neuronal genome integrity, potentially contributing to genetic diversity and offering therapeutic targets for neurological diseases such as Alzheimer's and Huntington's. The project involves genome-wide CRISPR screening, live-cell imaging, and mutation analysis.