# NIH Reporter #1DP2NS155520-01

RNA-Templated DNA Repair as a Genome Maintenance Pathway in Neurons

**Recipient:** Alessandra Brambati

**Award Amount:** $741,000.00
**Ceiling:** $741,000.00

**Awarded:** September 17, 2026

**Identifier:** 1DP2NS155520-01

Research project funded by NINDS to study RNA-templated DNA repair in neurons, exploring its role in genome maintenance and implications for neurological diseases.

### Description

This project aims to define how RNA-templated DNA repair maintains neuronal genome integrity, potentially contributing to genetic diversity and offering therapeutic targets for neurological diseases such as Alzheimer's and Huntington's. The project involves genome-wide CRISPR screening, live-cell imaging, and mutation analysis.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11395934)