Award
NIH Reporter #1R01NS146039-01A1
LTP impairment in Down Syndrome: mechanisms and treatments
Recipient
University of Colorado Denver
Award Amount
$557,084.00
Ceiling
$557,084.00
Awarded
September 17, 2026
Identifier
1R01NS146039-01A1
Research project funded by the National Institute of Neurological Disorders and Stroke to study cognitive impairments in Down Syndrome and Alzheimer's disease, focusing on synaptic plasticity and potential treatments involving CaMKII inhibition.
Description
This project aims to compare the molecular and cellular mechanisms underlying cognitive impairments in patients with Down Syndrome (DS) and Alzheimer’s disease (AD). The study focuses on impairments in synaptic plasticity, particularly hippocampal long-term potentiation (LTP), and investigates the role of amyloid beta (Aβ) and amyloid precursor protein (APP) in these processes. The research explores the potential of transient CaMKII inhibition to restore LTP and improve cognitive function.