# NIH Reporter #1R01NS146039-01A1

LTP impairment in Down Syndrome: mechanisms and treatments

**Recipient:** University of Colorado Denver

**Award Amount:** $557,084.00
**Ceiling:** $557,084.00

**Awarded:** September 17, 2026

**Identifier:** 1R01NS146039-01A1

Research project funded by the National Institute of Neurological Disorders and Stroke to study cognitive impairments in Down Syndrome and Alzheimer's disease, focusing on synaptic plasticity and potential treatments involving CaMKII inhibition.

### Description

This project aims to compare the molecular and cellular mechanisms underlying cognitive impairments in patients with Down Syndrome (DS) and Alzheimer’s disease (AD). The study focuses on impairments in synaptic plasticity, particularly hippocampal long-term potentiation (LTP), and investigates the role of amyloid beta (Aβ) and amyloid precursor protein (APP) in these processes. The research explores the potential of transient CaMKII inhibition to restore LTP and improve cognitive function.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11444342)