Award
NIH Reporter #1R21AA032579-01A1
iPSC-derived human liver organoids: Novel platform for determination of de novo and therapeutic actions of extracellular vesicles in AALD
Recipient
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
Award Amount
$414,750.00
Ceiling
$414,750.00
Awarded
September 11, 2026
Identifier
1R21AA032579-01A1
This award funds research using human liver organoids to study extracellular vesicles in alcohol-associated liver disease, aiming to identify new therapeutic targets.
Description
The project aims to understand hepatocyte extracellular vesicle (EV) production and action in alcohol-associated liver disease (AALD) using human liver organoids (HLO). It involves tracking EVs with a CD63 labeling system (EVTrack) and analyzing their RNA and protein cargo. The study will identify therapeutic miRNAs in EVs that could serve as targets for AALD treatment.