# NIH Reporter #1R21AA032579-01A1

iPSC-derived human liver organoids: Novel platform for determination of de novo and therapeutic actions of extracellular vesicles in AALD

**Recipient:** RESEARCH INST NATIONWIDE CHILDREN'S HOSP

**Award Amount:** $414,750.00
**Ceiling:** $414,750.00

**Awarded:** September 11, 2026

**Identifier:** 1R21AA032579-01A1

This award funds research using human liver organoids to study extracellular vesicles in alcohol-associated liver disease, aiming to identify new therapeutic targets.

### Description

The project aims to understand hepatocyte extracellular vesicle (EV) production and action in alcohol-associated liver disease (AALD) using human liver organoids (HLO). It involves tracking EVs with a CD63 labeling system (EVTrack) and analyzing their RNA and protein cargo. The study will identify therapeutic miRNAs in EVs that could serve as targets for AALD treatment.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11370712)