Award
NIH Reporter #5R33CA291185-03
Quantification of molecular interactions across the matrix spectrum enables cancer research.
Recipient
Vanderbilt University
Award Amount
$307,189.00
Ceiling
$307,189.00
Awarded
September 09, 2026
Identifier
5R33CA291185-03
Award to Vanderbilt University for advancing FSA-CIR technology to improve cancer research through sensitive, label-free molecular interaction analysis.
Description
Development, refinement, and validation of free-solution assay (FSA) technology and compensated Interferometric reader (CIR) to address a significant void in cancer research by providing a label-free, solution-phase, ultra-sensitive, enzyme-free technology compatible with any matrix. Useful for mechanism of action studies, membrane protein interaction studies, allosteric modulation, weak protein-protein interactions, assay development, biomarker discovery/validation, quantitative interactions, and ex-vivo measurements for first-in-human dose determinations.