# NIH Reporter #5R33CA291185-03

Quantification of molecular interactions across the matrix spectrum enables cancer research.

**Recipient:** Vanderbilt University

**Award Amount:** $307,189.00
**Ceiling:** $307,189.00

**Awarded:** September 09, 2026

**Identifier:** 5R33CA291185-03

Award to Vanderbilt University for advancing FSA-CIR technology to improve cancer research through sensitive, label-free molecular interaction analysis.

### Description

Development, refinement, and validation of free-solution assay (FSA) technology and compensated Interferometric reader (CIR) to address a significant void in cancer research by providing a label-free, solution-phase, ultra-sensitive, enzyme-free technology compatible with any matrix. Useful for mechanism of action studies, membrane protein interaction studies, allosteric modulation, weak protein-protein interactions, assay development, biomarker discovery/validation, quantitative interactions, and ex-vivo measurements for first-in-human dose determinations.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11398981)