Award
NIH Reporter #1R01AG100509-01
Enhancing deep restorative sleep in Alzheimer's disease model mice by neuromodulation of the globus pallidus pars externa
Recipient
Boston VA Research Institute, Inc.
Award Amount
$268,800.00
Ceiling
$268,800.00
Awarded
September 10, 2026
Identifier
1R01AG100509-01
The award funds research to enhance deep restorative sleep in Alzheimer's disease model mice through neuromodulation of the globus pallidus pars externa, aiming to improve cognition and slow disease progression.
Description
This project investigates neuromodulation of the globus pallidus pars externa (GPe) to enhance deep sleep, improve cognition, and slow disease progression in Alzheimer’s disease model mice. Approaches include cell-type specific inhibition via chemogenetics or optogenetics, pharmacological agents targeting GPe neurons, and long-term neuromodulation to delay cognitive decline.