# NIH Reporter #1R01AG100509-01

Enhancing deep restorative sleep in Alzheimer's disease model mice by neuromodulation of the globus pallidus pars externa

**Recipient:** Boston VA Research Institute, Inc.

**Award Amount:** $268,800.00
**Ceiling:** $268,800.00

**Awarded:** September 10, 2026

**Identifier:** 1R01AG100509-01

The award funds research to enhance deep restorative sleep in Alzheimer's disease model mice through neuromodulation of the globus pallidus pars externa, aiming to improve cognition and slow disease progression.

### Description

This project investigates neuromodulation of the globus pallidus pars externa (GPe) to enhance deep sleep, improve cognition, and slow disease progression in Alzheimer’s disease model mice. Approaches include cell-type specific inhibition via chemogenetics or optogenetics, pharmacological agents targeting GPe neurons, and long-term neuromodulation to delay cognitive decline.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11344420)