Award
NIH Reporter #5R01NS130100-03
Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis
Recipient
University of Colorado Denver
Award Amount
$411,495.00
Ceiling
$411,495.00
Awarded
September 17, 2026
Identifier
5R01NS130100-03
NIH awarded a grant to University of Colorado Denver to study the role of PLP1 antibodies in multiple sclerosis pathogenesis, focusing on antibody targets, prevalence, and lesion pathology to improve disease identification and therapy.
Description
This project investigates the role of complex PLP1 antibodies in MS pathogenesis, aiming to improve bioassays for disease identification and therapeutic strategies. The study involves developing recombinant antibodies, screening patient samples, analyzing MS lesions, and identifying epitopic targets using immunochemistry and transgenic mice models.