# NIH Reporter #5R01NS130100-03

Contribution of antibodies targeting PLP1-anchored membrane domains to multiple sclerosis pathogenesis

**Recipient:** University of Colorado Denver

**Award Amount:** $411,495.00
**Ceiling:** $411,495.00

**Awarded:** September 17, 2026

**Identifier:** 5R01NS130100-03

NIH awarded a grant to University of Colorado Denver to study the role of PLP1 antibodies in multiple sclerosis pathogenesis, focusing on antibody targets, prevalence, and lesion pathology to improve disease identification and therapy.

### Description

This project investigates the role of complex PLP1 antibodies in MS pathogenesis, aiming to improve bioassays for disease identification and therapeutic strategies. The study involves developing recombinant antibodies, screening patient samples, analyzing MS lesions, and identifying epitopic targets using immunochemistry and transgenic mice models.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11396438)