Award
NIH Reporter #1R21HL188991-01
Circadian Regulation of Disease Risk Genes and Its Implications for Chronotherapy and Biomarker Discovery
Recipient
University of Michigan at Ann Arbor
Award Amount
$234,000.00
Ceiling
$234,000.00
Awarded
September 17, 2026
Identifier
1R21HL188991-01
This NIH grant supports research on circadian biology and its impact on disease risk genes, utilizing computational and AI methods to advance precision medicine.
Description
The project explores how the circadian clock influences human physiology, particularly in relation to cardiovascular, pulmonary, hematologic, and sleep functions. It aims to analyze large-scale human transcriptomic datasets to identify rhythmic disease-associated genes, biomarkers, and therapeutic windows for chronotherapy. The project employs advanced computational algorithms such as JTK_Cycle, CYCLOPS, and TimeMachine to infer temporal gene expression patterns and misalignments in health and disease states. It also integrates AI-driven literature mining to connect circadian biomarkers with disease pathways, ultimately aiming to incorporate circadian biology into precision medicine.