# NIH Reporter #1R21HL188991-01

Circadian Regulation of Disease Risk Genes and Its Implications for Chronotherapy and Biomarker Discovery

**Recipient:** University of Michigan at Ann Arbor

**Award Amount:** $234,000.00
**Ceiling:** $234,000.00

**Awarded:** September 17, 2026

**Identifier:** 1R21HL188991-01

This NIH grant supports research on circadian biology and its impact on disease risk genes, utilizing computational and AI methods to advance precision medicine.

### Description

The project explores how the circadian clock influences human physiology, particularly in relation to cardiovascular, pulmonary, hematologic, and sleep functions. It aims to analyze large-scale human transcriptomic datasets to identify rhythmic disease-associated genes, biomarkers, and therapeutic windows for chronotherapy. The project employs advanced computational algorithms such as JTK_Cycle, CYCLOPS, and TimeMachine to infer temporal gene expression patterns and misalignments in health and disease states. It also integrates AI-driven literature mining to connect circadian biomarkers with disease pathways, ultimately aiming to incorporate circadian biology into precision medicine.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11445339)