Award
NIH Reporter #1K99AI201800-01
Unveiling mechanisms of RNA editing dysregulation
Recipient
University of California Berkeley
Award Amount
$120,312.00
Ceiling
$120,312.00
Awarded
August 27, 2026
Identifier
1K99AI201800-01
The project investigates how viral proteins disrupt RNA editing by ADAR enzymes and how that disruption affects immune responses and disease. It aims to identify viral and host factors involved, explain their mechanisms, and explore implications for antiviral strategies and RNA-based therapies.
Description
Project to uncover how viruses manipulate ADARs to evade host defenses, identify factors that alter RNA editing during infection, determine how they modulate ADAR activity, and examine effects on immune activation and disease outcomes.