Award
NIH Reporter #5K99HL181288-02
Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes
Recipient
University of Pennsylvania
Award Amount
$169,020.00
Ceiling
$169,020.00
Awarded
September 17, 2026
Identifier
5K99HL181288-02
The award supports research into the mechanisms behind mechanical memory in cardiomyocytes and its relationship to heart disease. The project will study epigenetic and DNA damage responses in cultured cells and living myocardial slices, while supporting the recipient’s research training.
Description
Project investigating how sustained mechanical stress affects cardiomyocyte nuclear signaling, chromatin architecture, gene expression, and DNA damage responses, including whether persistent changes can be reversed.