# NIH Reporter #5K99HL181288-02

Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes

**Recipient:** University of Pennsylvania

**Award Amount:** $169,020.00
**Ceiling:** $169,020.00

**Awarded:** September 17, 2026

**Identifier:** 5K99HL181288-02

The award supports research into the mechanisms behind mechanical memory in cardiomyocytes and its relationship to heart disease. The project will study epigenetic and DNA damage responses in cultured cells and living myocardial slices, while supporting the recipient’s research training.

### Description

Project investigating how sustained mechanical stress affects cardiomyocyte nuclear signaling, chromatin architecture, gene expression, and DNA damage responses, including whether persistent changes can be reversed.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11418997)