Award
NIH Reporter #5F31DA059092-04
Alpha7 nicotinic acetylcholine receptor allosteric modulation and native structure
Recipient
UT Southwestern Medical Center
Award Amount
$36,317.00
Ceiling
$36,317.00
Awarded
June 19, 2026
Identifier
5F31DA059092-04
A National Institute on Drug Abuse-funded research project studying α7 nicotinic acetylcholine receptor allosteric modulation and native structure to improve understanding of receptor biology and support future drug development.
Description
The project will investigate α7 nicotinic acetylcholine receptor modulation and structure, including determining high-resolution structures of α7 complexed with allosteric modulators, developing a method to purify native α7 from brain tissue, and determining structures of α7-containing channels using single-particle cryo-EM.