# NIH Reporter #5F31DA059092-04

Alpha7 nicotinic acetylcholine receptor allosteric modulation and native structure

**Recipient:** UT Southwestern Medical Center

**Award Amount:** $36,317.00
**Ceiling:** $36,317.00

**Awarded:** June 19, 2026

**Identifier:** 5F31DA059092-04

A National Institute on Drug Abuse-funded research project studying α7 nicotinic acetylcholine receptor allosteric modulation and native structure to improve understanding of receptor biology and support future drug development.

### Description

The project will investigate α7 nicotinic acetylcholine receptor modulation and structure, including determining high-resolution structures of α7 complexed with allosteric modulators, developing a method to purify native α7 from brain tissue, and determining structures of α7-containing channels using single-particle cryo-EM.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11360210)