Award
NIH Reporter #3UG3NS115637-04S2
Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain
Recipient
Stanford University
Award Amount
$409,088.00
Ceiling
$409,088.00
Awarded
September 19, 2026
Identifier
3UG3NS115637-04S2
Stanford University was awarded $409,088 by the National Institute of Neurological Disorders and Stroke for research translating ultrasound-triggered local ketamine delivery into a potential noninvasive, non-opioid treatment for chronic pain.
Description
Project to validate focused-ultrasound delivery of ketamine to the anterior cingulate cortex for chronic pain and translate the technology to a first-in-human clinical trial. The work includes scaling nanoparticle production, preclinical animal testing, and clinical evaluation of safety and efficacy in patients with chronic osteoarthritic pain.