# NIH Reporter #3UG3NS115637-04S2

Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain

**Recipient:** Stanford University

**Award Amount:** $409,088.00
**Ceiling:** $409,088.00

**Awarded:** September 19, 2026

**Identifier:** 3UG3NS115637-04S2

Stanford University was awarded $409,088 by the National Institute of Neurological Disorders and Stroke for research translating ultrasound-triggered local ketamine delivery into a potential noninvasive, non-opioid treatment for chronic pain.

### Description

Project to validate focused-ultrasound delivery of ketamine to the anterior cingulate cortex for chronic pain and translate the technology to a first-in-human clinical trial. The work includes scaling nanoparticle production, preclinical animal testing, and clinical evaluation of safety and efficacy in patients with chronic osteoarthritic pain.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11540446)