Award
NIH Reporter #2P50AA024333-11
Project One - Gut Microbial Metabolites as Drivers of Ethanol-Induced Injury
Recipient
Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
Award Amount
$327,433.00
Ceiling
$327,433.00
Awarded
July 30, 2026
Identifier
2P50AA024333-11
This NIH-funded project studies the role of gut microbial metabolites in alcohol-induced liver injury, aiming to identify biomarkers and therapeutic targets for ALD using advanced mouse models.
Description
Research project investigating gut microbial-derived aromatic amino acid metabolites as biomarkers and therapeutic targets in alcohol-associated liver disease (ALD). The study uses innovative gnotobiotic mouse models to understand how these metabolites protect against ethanol-induced liver injury and aims to develop biomarkers to distinguish patients with alcoholic hepatitis, metabolic-associated fatty liver disease, and metabolic dysfunction-associated steatohepatitis.