# NIH Reporter #2P50AA024333-11

Project One - Gut Microbial Metabolites as Drivers of Ethanol-Induced Injury

**Recipient:** Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

**Award Amount:** $327,433.00
**Ceiling:** $327,433.00

**Awarded:** July 30, 2026

**Identifier:** 2P50AA024333-11

This NIH-funded project studies the role of gut microbial metabolites in alcohol-induced liver injury, aiming to identify biomarkers and therapeutic targets for ALD using advanced mouse models.

### Description

Research project investigating gut microbial-derived aromatic amino acid metabolites as biomarkers and therapeutic targets in alcohol-associated liver disease (ALD). The study uses innovative gnotobiotic mouse models to understand how these metabolites protect against ethanol-induced liver injury and aims to develop biomarkers to distinguish patients with alcoholic hepatitis, metabolic-associated fatty liver disease, and metabolic dysfunction-associated steatohepatitis.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11232482)