Award
NIH Reporter #1F30CA310665-01
Leveraging a neuroepithelial stem cell model to determine regulators of differentiation failure in NF2-mutant neural progenitors
Recipient
Indiana University Indianapolis
Award Amount
$56,622.00
Ceiling
$56,622.00
Awarded
May 07, 2026
Identifier
1F30CA310665-01
NIH-funded research at Indiana University Indianapolis studying differentiation failure in NF2-mutant neural progenitors and testing TEAD inhibitors as potential treatments for spinal ependymoma.
Description
The project investigates why NF2-mutant neuroepithelial stem cells fail to differentiate and form clusters in vitro, identifies regulators of this failure, and tests whether TEAD inhibitors can restore differentiation. The longer-term goal is to identify therapeutic approaches for NF2-mutant spinal ependymoma.