# NIH Reporter #1F30CA310665-01

Leveraging a neuroepithelial stem cell model to determine regulators of differentiation failure in NF2-mutant neural progenitors

**Recipient:** Indiana University Indianapolis

**Award Amount:** $56,622.00
**Ceiling:** $56,622.00

**Awarded:** May 07, 2026

**Identifier:** 1F30CA310665-01

NIH-funded research at Indiana University Indianapolis studying differentiation failure in NF2-mutant neural progenitors and testing TEAD inhibitors as potential treatments for spinal ependymoma.

### Description

The project investigates why NF2-mutant neuroepithelial stem cells fail to differentiate and form clusters in vitro, identifies regulators of this failure, and tests whether TEAD inhibitors can restore differentiation. The longer-term goal is to identify therapeutic approaches for NF2-mutant spinal ependymoma.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11317885)