Award
NIH Reporter #1F31HL184619-01
Molecular mechanisms of muscle thin-filament length regulation
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
May 07, 2026
Identifier
1F31HL184619-01
Research project funded to study molecular mechanisms regulating muscle thin-filament length, linked to severe myopathies, aiming to provide insights for treatment development.
Description
This project investigates the molecular mechanisms by which Lmod and SH3BGR regulate thin filament pointed end length and dynamics. Dysregulation of this process contributes to severe human myopathies, including dilated cardiomyopathy, nemaline myopathy, and congenital heart disease. The grant aims to elucidate how Lmod and SH3BGR are linked to disease and provide insights for treatment development.