# NIH Reporter #1F31HL184619-01

Molecular mechanisms of muscle thin-filament length regulation

**Recipient:** University of Pennsylvania, Philadelphia, PA, United States

**Award Amount:** $50,114.00
**Ceiling:** $50,114.00

**Awarded:** May 07, 2026

**Identifier:** 1F31HL184619-01

Research project funded to study molecular mechanisms regulating muscle thin-filament length, linked to severe myopathies, aiming to provide insights for treatment development.

### Description

This project investigates the molecular mechanisms by which Lmod and SH3BGR regulate thin filament pointed end length and dynamics. Dysregulation of this process contributes to severe human myopathies, including dilated cardiomyopathy, nemaline myopathy, and congenital heart disease. The grant aims to elucidate how Lmod and SH3BGR are linked to disease and provide insights for treatment development.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11314858)