NIH Reporter #1F32EY038566-01A1

Deciphering the role of cellular and physiological mechanisms in glaucoma via integrative genomics, imaging, and computational modeling

The National Eye Institute-funded project studies genetic, cellular, and vascular mechanisms of primary open-angle glaucoma using genomic data, fundus imaging, and computational blood-flow models, with the goal of better identifying disease subtypes and informing personalized therapies.

Description

Research project integrating cell type-specific polygenic risk scores, eye-tissue multi-omics, ocular imaging, and computational modeling of retinal blood flow to investigate cellular and physiological mechanisms underlying primary open-angle glaucoma and support improved diagnosis and targeted treatments.

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