Award
NIH Reporter #1R01NS150462-01
Quantifying Biomechanical and Perfusion Abnormalities in Drug-Resistant Epilepsy: Novel MR Imaging Markers of Seizure Foci and Underlying Gliosis
Recipient
Icahn School of Medicine at Mount Sinai
Award Amount
$646,706.00
Ceiling
$646,706.00
Awarded
August 14, 2026
Identifier
1R01NS150462-01
NIH-funded research project studying whether MRE and ASL can improve localization of seizure foci and support surgical planning for people with drug-resistant epilepsy.
Description
The project evaluates magnetic resonance elastography (MRE) and arterial spin labeling (ASL) as imaging markers to localize and characterize epileptic foci in drug-resistant epilepsy, including patients without visible lesions. It will investigate brain biomechanics and perfusion in patients and healthy controls and correlate imaging findings with glial activation and histopathology.