# NIH Reporter #1R01NS150462-01

Quantifying Biomechanical and Perfusion Abnormalities in Drug-Resistant Epilepsy: Novel MR Imaging Markers of Seizure Foci and Underlying Gliosis

**Recipient:** Icahn School of Medicine at Mount Sinai

**Award Amount:** $646,706.00
**Ceiling:** $646,706.00

**Awarded:** August 14, 2026

**Identifier:** 1R01NS150462-01

NIH-funded research project studying whether MRE and ASL can improve localization of seizure foci and support surgical planning for people with drug-resistant epilepsy.

### Description

The project evaluates magnetic resonance elastography (MRE) and arterial spin labeling (ASL) as imaging markers to localize and characterize epileptic foci in drug-resistant epilepsy, including patients without visible lesions. It will investigate brain biomechanics and perfusion in patients and healthy controls and correlate imaging findings with glial activation and histopathology.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11432253)