Award
NIH Reporter #5K08HL171943-02
Lymph Node Stromal Cells in the Pathogenesis, Diagnosis, and Treatment of Unicentric Castleman Disease
Recipient
University of Pennsylvania
Award Amount
$164,860.00
Ceiling
$164,860.00
Awarded
September 08, 2026
Identifier
5K08HL171943-02
Research project funded by NHLBI to investigate lymph node stromal cells' role in Unicentric Castleman Disease, focusing on genetic mutations and disease mechanisms to enhance diagnosis and treatment.
Description
This project aims to study the role of lymph node stromal cells in the development, diagnosis, and treatment of Unicentric Castleman Disease. The research hypothesizes that clonal expansion of stromal cells, potentially driven by PDGFRB mutations, contributes to disease pathogenesis. The study will investigate cellular identity, clonality, and functional consequences of mutations to improve diagnostics and therapies.