# NIH Reporter #5K08HL171943-02

Lymph Node Stromal Cells in the Pathogenesis, Diagnosis, and Treatment of Unicentric Castleman Disease

**Recipient:** University of Pennsylvania

**Award Amount:** $164,860.00
**Ceiling:** $164,860.00

**Awarded:** September 08, 2026

**Identifier:** 5K08HL171943-02

Research project funded by NHLBI to investigate lymph node stromal cells' role in Unicentric Castleman Disease, focusing on genetic mutations and disease mechanisms to enhance diagnosis and treatment.

### Description

This project aims to study the role of lymph node stromal cells in the development, diagnosis, and treatment of Unicentric Castleman Disease. The research hypothesizes that clonal expansion of stromal cells, potentially driven by PDGFRB mutations, contributes to disease pathogenesis. The study will investigate cellular identity, clonality, and functional consequences of mutations to improve diagnostics and therapies.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11394294)