Award
NIH Reporter #1F31CA301909-01A1
Uncovering the roles of symmetric dimethylation of arginine on ZNF326
Recipient
Virginia Polytechnic Institute and State University
Award Amount
$45,528.00
Ceiling
$45,528.00
Awarded
May 14, 2026
Identifier
1F31CA301909-01A1
Research project funded by the National Cancer Institute to study the enzyme PRMT5 and its role in cancer, focusing on molecular mechanisms and potential therapeutic targets.
Description
The project aims to understand the roles and binding mechanisms of the enzyme PRMT5, a therapeutic target in certain cancers. It focuses on the methylation of substrates like ZNF326 and their role in pancreatic ductal adenocarcinoma. The study involves co-immunoprecipitation mass spectrometry, mutant analysis, and RNA sequencing to elucidate PRMT5's function and interactions, potentially leading to targeted cancer therapies.